X. Qi

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

This study generates blastocyst-like structures from porcine pluripotent stem cells using chemical induction, achieving up to 80% efficiency and mimicking natural blastocysts in morphology and transcriptome.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

This study identifies S-HsfA2 in Arabidopsis as a factor that prevents hyperactivation of the heat stress response, balancing heat resistance and growth.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Inflammatory Cytokines Can Induce Synthesis Of Type-I Interferon

The paper shows inflammatory cytokines like TNF-α and IL-1β can induce IFN-β through RIG-I signaling pathway activation via PACT and MAPK/p38 phosphorylation.

Linking root-associated fungal and bacterial functions to root economics

The paper links fungal and bacterial functions in root-associated communities to root economics traits in a subtropical forest.

EMDiffuse: a diffusion-based deep learning method augmenting ultrastructural imaging and volume electron microscopy

EMDiffuse enhances volume electron microscopy by using diffusion models to improve resolution and enable isotropic reconstruction of large biological volumes.

Quantification of glutathione with high throughput live-cell imaging

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

The paper compares placental transcriptomes and histology between native Tibetans and Han migrants, finding sex-biased expression divergence and adaptive histological changes in male-infant placentas.

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASIL

This study uses iPSC-derived neurovascular cells to show impaired BBB function and disrupted tight junctions in CADASIL, highlighting early neurovascular interaction defects.

NanoMOFs with Encapsulated Photosensitizer: Accumulation in Chlamydia trachomatis Inclusions and Antimicrobial Effects

This study demonstrates that iron-based nanoMOFs can co-localize with Chlamydia trachomatis in macrophages and exhibit antimicrobial effects through photodynamic inactivation and reduced bacterial load.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

A Genome-scale Screen Reveals ANTXR1, Heparan Sulfate and Neu5Gc as Host Factors mediating Seneca Valley virus Entry into Porcine Cells

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

PRMT5 is a therapeutic target in choroidal neovascularization

This study identifies PRMT5 as a therapeutic target for neovascular age-related macular degeneration by showing its inhibition reduces NF-κB activity and angiogenic properties in ocular endothelial cells.

Dual-Resolving of Lipid Positional and Geometric Isomers of C=C Bonds via Bifunctional Photocycloaddition-Photoisomerization Reaction System and Mass Spectrometry

This paper develops a bifunctional reaction system to simultaneously resolve lipid positional and geometric isomers using mass spectrometry, revealing structural patterns in bacteria and tracking changes in mouse brain ischemia.

Concomitant Pyroptotic and Apoptotic Cell Death Triggered in Monocytes Infected by Zika Virus

This study shows that Zika virus infection of monocytes triggers both apoptosis and pyroptosis, with pyroptosis being NLRP3-dependent and caspase-1-mediated.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

A genotype independent DMP-HI system in dicot crops

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

Brassica rapa domestication: untangling wild and feral forms and convergence of crop morphotypes

This study clarifies the domestication history of Brassica rapa by analyzing genetic diversity and identifying wild and feral forms, suggesting turnips were the first domesticated type.

New insights on folliculogenesis and follicular placentation in marine viviparous fish black rockfish (Sebastes schlegelii)

This study identifies a novel folliculogenesis and follicular placentation mechanism in black rockfish, highlighting hormonal changes and conserved genes in placental development.

Identification of Nocardia species using Autof MS 1000 and Bruker MALDI-TOF MS systems: A comparison

This study compares the performance of Autof MS 1000 and Bruker MALDI-TOF MS systems in identifying Nocardia species using clinical isolates and sequence analysis as a reference.

Genes derived from ancient polyploidy have higher genetic diversity and are associated with domestication in Brassica rapa

The paper identifies candidate genes associated with domestication in Brassica rapa and finds that genes from ancient polyploidy are more diverse and linked to domestication.

Qualitative and quantitative bioanalytical methods validation of aristolochic acid DNA adducts and application in human formalin-fixed paraffin-embedded hepatocellular carcinoma tissues

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

The Manifold Actions of Signaling Peptides on Subcellular Dynamics of a Receptor Specify Stomatal Cell Fate

The paper shows how different signaling peptides alter the subcellular dynamics of a receptor to determine stomatal cell fate in plants.

Host fruit as a suitable bacteria growth substrate that promotes larval development of Bactrocera dorsalis (Diptera: Tephritidae)

This study shows that banana supports better larval development and bacterial growth in Bactrocera dorsalis compared to apple, suggesting a link between host fruit quality and gut microbiota.

Genome-wide DNA polymorphisms in four Actinidia arguta genotypes based on whole-genome re-sequencing

The paper identifies genome-wide SNPs and InDels in four Actinidia arguta genotypes using whole-genome re-sequencing and links them to functional genes involved in stress responses and hormone signaling.