Author

K. Kania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1

Frequent Co-Authors

A. D. Reed· 1 shared A. Nicholls· 1 shared A. Schambach· 1 shared A. Steif· 1 shared A. Szyposzynska· 1 shared A.-J. Twigger· 1 shared C. Mussolino· 1 shared CRUK IMAXT Grand Challenge Team· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. D. Reed

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Human Breast Cell Atlas Mapping the Homeostatic Cellular Shifts in the Adult Breast

A. D. Reed, S. Pensa, A. Steif, J. Stenning, D. Kunz, P. He, A.-J. Twigger, K. Kania, R. Barrow, I. Goulding, J. Gomm, L. Jones, J. Marioni, W. T. Khaled

This study creates a Human Breast Cell Atlas using scRNA-seq from 55 donors, identifying 41 cell subclusters and showing how factors like age and BRCA mutations affect breast homeostasis and immune cell states.

bioRxiv · Apr 21, 2023 · PreprintCancer Biology

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

M. Takahashi, T. So, K. Williamson, Z. Hosseini, K. Kania, M. Ruhle, T. Mann, M. J. Schujis, P. Coupland, D. Naisbitt, T. Y. F. Halim, P. A. Lyons, P. Lio, K. Okkenhaug, D. J. Adams, , J. E. D. Thaventhiran

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

bioRxiv · Mar 16, 2023Immunology

Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.

S. A. Wild, I. G. Cannell, K. Kania, A. Nicholls, D. Bressan, CRUK IMAXT Grand Challenge Team, G. J. Hannon, K. Sawicka

The paper uses clonal transcriptomics to identify mechanisms of chemoresistance in TNBC and suggests asparagine deprivation as a potential combination therapy.

bioRxiv · Dec 9, 2021Cancer Biology

Efficient in vivo genome editing mediated by stem cells-derived extracellular vesicles carrying designer nucleases

S. Bobis-Wozowicz, K. Kania, K. Nit, N. Blazowska, K. Kmiotek-Wasylewska, M. Paw, E. Karnas, A. Szyposzynska, M. Tyszka-Czochara, O. Woznicka, D. Boruczkowski, C. Mussolino, P. P. Łabaj, A. Schambach, Z. Madeja, , E. Zuba-Surma

This study demonstrates that stem cell-derived extracellular vesicles can deliver designer nucleases in vivo, achieving up to 50% gene knockout in the liver.

bioRxiv · Feb 25, 2021 · PreprintBioengineering