Author

K. Khatua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Organism:virus· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Xu· 5 shared Y. Ma· 5 shared C.-C. Cho· 4 shared E. C. Vatansever· 4 shared L. Blankenship· 4 shared W. R. Liu· 4 shared Y. R. Alugubelli· 4 shared G. Yu· 3 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

S. Xu

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5 papers

Recent·Most cited

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease

Y. R. Alugubelli, J. Xiao, K. Khatua, S. Kumar, Y. Ma, X. Ma, V. R. Vulupala, S. Atla, L. Blankenship, D. Coleman, B. W. Neuman, W. Liu, S. Xu

This paper develops first-in-class PROTAC degraders of SARS-CoV-2 main protease, showing they reduce MPro levels and exhibit anti-SARS-CoV-2 activity.

bioRxiv · Sep 29, 2023Biochemistry

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

K. Khatua, Y. R. Alugubelli, K. Yang, V. Reddy, L. Blankenship, D. Coleman, S. Atla, S. Chaki, Z. Geng, X. Ma, J. Xiao, P.-H. Chen, C.-C. Cho, E. C. Vatansever, Y. Ma, , W. R. Liu

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

bioRxiv · Apr 11, 2023 · PreprintBiochemistry

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Z. Z. Geng, S. Atla, N. Shaabani, V. R. Vulupara, K. S. Yang, Y. R. Alugubelli, K. Khatua, P.-H. C. Chen, J. Xiao, L. R. Blankenship, X. R. Ma, E. C. Vatansever, C.-C. Cho, Y. Ma, R. Allen, , W. R. Liu

This study systematically evaluates dipeptidyl inhibitors of SARS-CoV-2 main protease, identifying compounds with high antiviral potency and low cytotoxicity.

bioRxiv · Jan 17, 2023Biochemistry

The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

Y. R. Alugubelli, Z. Z. Geng, K. Yang, N. Shaabani, K. Khatua, X. R. Ma, E. C. Vatansever, C.-C. Cho, Y. Ma, L. Blankenship, G. Yu, B. Sankaran, P. Li, R. Allen, H. Ji, , W. R. Liu

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

bioRxiv · Dec 18, 2021 · PreprintBiochemistry

The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

Y. Ma, K. Yang, Z. Z. Geng, Y. R. Alugubellia, N. Shaabani, E. C. Vatansever, X. R. Ma, C.-C. Cho, K. Khatua, L. Blankenship, G. Yu, B. Sankaran, P. Li, R. Allen, H. Ji, , W. R. Liu

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

bioRxiv · Dec 18, 2021 · PreprintBiochemistry