G. Yu

Oligopeptide (FK)4 facilitates the determination of the absolute stereochemistry of chiral organic compounds via NMR Spectroscopy

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.

Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

Modeling platinum resistance in a stem-like patient-derived ovarian cancer sample

This study develops a patient-derived model of cisplatin resistance in ovarian cancer stem-like cells and identifies molecular and functional changes associated with resistance.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

Prostate cancer-induced endothelial-to-osteoblast transition generates an immunosuppressive bone tumor microenvironment

This study identifies a prostate cancer-induced endothelial-to-osteoblast transition that creates an immunosuppressive bone tumor microenvironment, reducing the effectiveness of immune checkpoint therapy in bone metastatic castrate-resistant prostate cancer.

Structural basis for the concerted antiphage activity in the SIR2-HerA system

This study determines the cryo-EM structures of SIR2, HerA, and their complex, revealing their structural basis for antiphage activity and functional interactions.

Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

The paper identifies a mesenchymal-hepatocyte hybrid population that drives liver regeneration by regenerating 50% of new hepatocytes and repopulating liver zones 1 and 3.

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

Insm1 regulates the development of mTECs and immune tolerance

This study shows that Insm1 regulates mTEC development and immune tolerance by interacting with Aire and affecting gene expression.

Molecular Mechanism for Bacterial Degradation of Plant Hormone Auxin

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

Alendronate Conjugate for Targeted Delivery to Bone-Forming Prostate Cancer

This paper develops a Cy5.5-alendronate conjugate for targeted drug delivery to bone-forming prostate cancer metastases, showing enhanced bone targeting and reduced systemic circulation.

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation

The paper uses locus-specific proteomics to identify proteins associated with the V region chromatin in SHM and validates their function using a Dot1L inhibitor.

Ralstonia solanacearum alters root developmental programs in auxin-dependent and independent manners

This study shows Ralstonia solanacearum alters root development in Arabidopsis through auxin-dependent and independent mechanisms, including promoting xylem differentiation and root hair formation.

Aridity modulates biogeographic distribution and community assembly of cyanobacterial morphotypes in drylands

This study examines how aridity affects the distribution and community assembly of cyanobacterial morphotypes in drylands, finding that stochastic processes dominate but aridity influences the balance between determinism and stochasticity.

PvC3H29 interacts with and inhibits DNA binding of PvNAPs to finetune leaf senescence in switchgrass (Panicum virgatum)

PvC3H29 interacts with PvNAP1&2 to inhibit their transactivation on chlorophyll catabolism and leaf senescence in switchgrass.

Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanism

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.

HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus Maturation

This study determines the 3D structure of HIV-2 immature Gag lattice using cryo-EM and identifies structural features critical for particle release and infectivity.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

A wheat kinase and immune receptor form the host-specificity barrier against the blast fungus

The paper identifies two wheat resistance genes that act as host-specificity barriers against the blast fungus and describes assays to incorporate these genes into wheat cultivars.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

Stem embolism vulnerability curve depends on methods used: is there a fifth mechanism of cavitation?

This paper investigates how different methods for measuring stem embolism vulnerability affect results, finding that nano-particles may induce early cavitation and that the origin of these particles might be from living cells near vessels.

Activation of retinoic acid receptor reduces metastatic prostate cancer bone lesions through blocking endothelial-to-osteoblast transition

Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition

This study shows that prostate tumor-induced stromal reprogramming produces Tenascin C, which promotes metastasis by inhibiting YAP/TAZ through 5{beta}1 integrin.