Author

P.-H. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

S. L. Schmid· 2 shared A. Lu· 1 shared A. M. Lakoduk· 1 shared A. Smith· 1 shared B. Faubert· 1 shared B. Ko· 1 shared B. Neuman· 1 shared B. Timmons· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

S. L. Schmid

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

K. Khatua, Y. R. Alugubelli, K. Yang, V. Reddy, L. Blankenship, D. Coleman, S. Atla, S. Chaki, Z. Geng, X. Ma, J. Xiao, P.-H. Chen, C.-C. Cho, E. C. Vatansever, Y. Ma, , W. R. Liu

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

bioRxiv · Apr 11, 2023 · PreprintBiochemistry

TWAS coupled with eQTL analysis reveals the genetic connection between gene expression and flowering time in Arabidopsis

P.-S. Chien, P.-H. Chen, C.-R. Lee, T.-J. Chiou

This study combines TWAS and eQTL analysis to identify genetic connections between gene expression and flowering time in Arabidopsis, revealing regulatory modules involving FRI-FLC-SOC1.

bioRxiv · Dec 7, 2022Plant Biology

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

P.-H. CHEN, L. Cai, C. Yang, J. Kim, B. Faubert, L. Boroughs, B. Ko, J. Sudderth, E. A. McMillan, L. Girard, M. Peyton, K. Huffman, M. D. Shields, D. Shames, H. S. Kim, , R. J. DeBerardinis

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

bioRxiv · Mar 11, 2019Cancer Biology

Glycosylation of gigaxonin regulates intermediate filaments: Novel molecular insights into giant axonal neuropathy

P.-H. CHEN, T. Smith, J. Hu, S. Pan, A. Smith, A. Lu, J.-T. Chi, M. Boyce

This study identifies O-GlcNAcylation of gigaxonin as a regulatory mechanism linking metabolism to intermediate filament proteostasis, offering insights into giant axonal neuropathy.

bioRxiv · Jan 26, 2019 · PreprintCell Biology

Mutant p53 triggers a dynamin-1/APPL1 endosome feedback loop that regulates β1 integrin recycling and migration

A. M. Lakoduk, P. Roudot, M. Mettlen, H. M. Grossman, P.-H. Chen, S. L. Schmid

This study identifies a feedback loop involving mutant p53, dynamin-1, and APPL1 endosomes that enhances β1 integrin recycling and cell migration in cancer.

bioRxiv · Sep 5, 2018Cell Biology

Mammalian stringent-like response mediated by the cytosolic NADPH phosphatase MESH1

C.-K. C. Ding, J. Rose, J. Wu, T. Sun, K.-Y. Chen, P.-H. Chen, E. Xu, S. Tian, J. Akinwuntan, Z. Guan, P. Zhou, J.-T. A. Chi

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.

bioRxiv · May 17, 2018Biochemistry

A non-canonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells

S. Srinivasan, C. J. Burckhardt, M. Bhave, Z. Chen, P.-H. Chen, X. Wang, G. Danuser, S. L. Schmid

This study identifies a non-scission role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through interactions with SNX9.

bioRxiv · Jan 22, 2018Cell Biology