MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy
Y. Kim, C. Li, C. Gu, E. Tycksen, A. Puri, T. A. Pietka, J. Sivapackiam, Y. Fang, K. Kidd, S.-J. Park, B. G. Johnson, S. Kmoch, J. S. Duffield, A. J. Bleyer, M. E. Jackrel, , Y. M. Chen
This study shows that MANF improves autophagy and mitochondrial function in a mouse model of ADTKD-UMOD, offering a potential therapy for proteinopathies.
bioRxiv · Jan 10, 2023 · PreprintCell Biology