L. Ye

The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth

The study identifies 20 cell types in Arabidopsis root secondary growth using single-cell RNA sequencing and lineage tracing, revealing dynamic parenchyma cell diversity and functional roles.

Cell fate plasticity of xylem-pole-pericycle in Arabidopsis roots

This study investigates the cell fate plasticity of xylem-pole-pericycle cells in Arabidopsis roots, showing how auxin and cytokinins regulate their ability to form lateral roots or contribute to cambium.

Structure and function of an intermediate GPCR-G protein complex

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice

IntelliR is a pipeline for analyzing IntelliCage data, enabling automated assessment of spatial, episodic-like, and working memory in mice, with validation using control and neuron-ablated cohorts.

12R-HETE acts as an endogenous ligand of Nur77 in intestine and regulates ILC3s plasticity

This study identifies 12R-HETE as an endogenous ligand of Nur77 that regulates ILC3s plasticity and gut immunity.

Perturbomics of tumor-infiltrating NK cells

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

Transcription factor GLK2 regulates key steps of anthocyanin biosynthesis to antagonize photo-oxidative stress during greening of Arabidopsis seedlings

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

Brainstem Dbh+ Neurons Control Chronic Allergen-Induced Airway Hyperreactivity

This study identifies Dbh+ neurons in the brainstem as critical for chronic allergen-induced airway hyperreactivity through molecular, anatomical, and functional analyses.

Characterization of a novel botybirnavirus with a unique dsRNA infecting Didymella theifolia from tea plants

The paper characterizes a novel botybirnavirus, DtBRV1, found in Didymella theifolia, which infects tea plants, and identifies a unique dsRNA unit with distinct molecular features.

Influence of MUC1 on trafficking of TRPV5 and TRPV6 and in vivo Ca2+ homeostasis.

This study investigates how MUC1 affects TRPV5 and TRPV6 trafficking and Ca2+ homeostasis, finding that MUC1 reduces endocytosis of these channels and influences blood Ca2+ levels in mice and humans.

HY5 regulates GLK transcription factors to orchestrate photomorphogenesis in Arabidopsis thaliana

The paper shows HY5 regulates GLK transcription factors to control chloroplast development and hypocotyl elongation during light-induced seedling development in Arabidopsis.

CURLYLEAF is a key modulator of apoplast water status in Arabidopsis leaf

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

Gibberellins promote polar auxin transport to regulate stem cell fate decisions in cambium

This study shows gibberellins regulate stem cell fate in vascular cambium by modulating auxin transport, affecting xylem and phloem differentiation.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

This paper develops a bispecific antibody that targets both RBD and S2 of SARS-CoV-2, showing improved neutralization against Omicron and other variants compared to its parental monoclonal antibodies.

Targeting fatty acid beta-oxidation impairs monocyte differentiation and prolongs heart allograft survival

This study shows that inhibiting fatty acid beta-oxidation impairs monocyte differentiation and improves heart allograft survival by reducing immune cell infiltration.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

PLURIPOTENT STEM CELL-DERIVED CARDIOVASCULAR PROGENITORS DIFFFERENTIATED ON LAMININ 221 REGENERATE AND IMPROVE FUNCTION OF INFARCTED SWINE HEARTS

This paper differentiates pluripotent stem cells into cardiovascular progenitors on laminin 221 and shows improved heart function in infarcted pigs.

Maxent modeling for predicting the potential distribution of global talaromycosis

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

Talaromyces marneffei promotes M2 polarization of human macrophages by downregulating SOCS3 expression and activating TLR9 pathway

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

Overexpression of EiKCS confers paraquat-tolerance in rice (Oryza sativa L.) by promoting polyamine pathway

Overexpressing EiKCS from goosegrass in rice increases polyamine levels and enhances paraquat tolerance through improved antioxidant capacity and photosynthesis.

Ligand Modulation of the Conformational Dynamics of the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence

This study uses single-molecule fluorescence to analyze how ligands modulate conformational dynamics of the A2A adenosine receptor, revealing ligand-dependent changes in state transitions and dynamics.

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

This study identifies a molecular pathway by which enteroendocrine cells respond to bacterial tryptophan catabolites, activating enteric and vagal neurons through Trpa1 signaling.