C. Gu

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

Vitamin D attenuates diabetic myocardial injury via the Erbb4/ferroptosis axis

This study shows vitamin D reduces diabetic myocardial injury by inhibiting the Erbb4/ferroptosis pathway in both in vivo and in vitro models.

Multiscale Bayesian Simulations Reveal Functional Chromatin Condensation of Gene Loci

This paper introduces Hi-C metainference, a Bayesian method to model chromatin organization, revealing that gene loci in mouse embryonic stem cells are dynamically condensed and organized as crumpled globules.

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

Nondestructive Spatial Lipidomics for Glioma Classification

This study develops a nondestructive method using nanoneedles and mass spectrometry to perform spatial lipidomics on brain tissues, enabling accurate glioma classification without damaging the tissue.

MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy

This study shows that MANF improves autophagy and mitochondrial function in a mouse model of ADTKD-UMOD, offering a potential therapy for proteinopathies.

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

This study uses capillary electrophoresis mass spectrometry to identify new isomers of inositol pyrophosphates in mammalian tissues and patient samples.

Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

The paper identifies a truncated suPAR fragment, D2D3, that causes kidney disease and autoimmune diabetes by impairing pancreatic beta-cell function and kidney health.

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.1 and BA.2 variants and their mouse origins

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

The bladder microbiome, metabolome, cytokines, and phenotypes in patients with systemic lupus erythematosus

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery

Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

This study identifies vitronectin-integrin signaling as a mechanism by which pericytes regulate blood-CNS barrier integrity through inhibition of transcytosis in endothelial cells.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry (CE-ESI-MS)

This paper develops a CE-ESI-MS method to analyze inositol phosphates and pyrophosphates, revealing unknown synthesis pathways in mammals.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

Fully human single-domain antibodies against SARS-CoV-2

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells

The paper shows DNA methylation's long-range and local correlations reflect chromatin spatial organization across different cell types.