K. Lopez

Nanobodies against SARS-CoV-2 reduced virus load in the brain of challenged mice and neutralized Wuhan, Delta and Omicron Variants

This study develops nanobodies against SARS-CoV-2 that neutralize multiple variants and reduce viral load in the brain of infected mice.

Development of Scaffold-free 3D Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis

The paper develops scaffold-free 3D cholangiocyte organoids to study primary sclerosing cholangitis progression and confirms PSC-specific phenotypes.

Assessing pyrethroid resistance status in the Culex pipiens complex (Diptera: Culicidae) from the northwest suburbs of Chicago, Illinois using Cox regression of bottle bioassays and other detection tools

The paper assesses pyrethroid resistance in Culex pipiens from Chicago suburbs using bottle bioassays and Cox regression, finding resistance mechanisms vary by location.

Tracking of Anopheles stephensi in Ethiopia using mitochondrial DNA reveals pattern of spread

This study tracks the spread of Anopheles stephensi in Ethiopia using mitochondrial DNA, revealing a South Asian origin and recent expansion into southeastern regions with multiple introductions.

Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis

This study shows caspase-2 regulates S-phase cell cycle events to reduce DNA damage accumulation without relying on its pro-apoptotic function.

Dual TCR-alpha expression on MAIT cells as a potential confounder of TCR interpretation

The paper identifies dual TCR-alpha expression on MAIT cells as a confounder in TCR interpretation, showing non-TRAV1-2 TCRs do not bind MR1-5-OP-RU tetramer.

A machine learning approach to optimizing cell-free DNA sequencing panels: with an application to prostate cancer

This paper uses machine learning to design a targeted sequencing panel for detecting tumor variants in cell-free DNA from prostate cancer patients, showing improved performance over existing methods.

Cell-free DNA as a biomarker for prostate cancer: elevated concentration and decreased fragment size

This study finds that higher plasma cfDNA concentrations and smaller fragment sizes are associated with more advanced prostate cancer.

Comparison of the knockdown resistance locus (kdr) in Anopheles stephensi, An. arabiensis, and Culex pipiens s.l. suggests differing mechanisms of pyrethroid resistance in east Ethiopia

The study compares kdr mutations in three mosquito species in East Ethiopia, finding differences in pyrethroid resistance mechanisms across species.

Microbial Source Tracking in the Love Creek Watershed, Delaware (USA)

The paper uses microbial source tracking to identify fecal contamination sources in Love Creek watershed, finding wildlife as the main contributor and domestic animals as secondary sources.

Geographical distribution of Anopheles stephensi in eastern Ethiopia

The paper surveys Anopheles stephensi distribution in eastern Ethiopia using morphological and molecular methods, confirming its presence and co-occurrence with Aedes aegypti in larval habitats.