Author

J. Rossjohn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Organism:human· 6 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Petersen· 3 shared K. Kedzierska· 3 shared B. Moody· 2 shared I. Van Rhijn· 2 shared J. P. Vivian· 2 shared L. C. Rowntree· 2 shared L. Loh· 2 shared P. Thomas· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

J. Petersen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

T. V. Cornforth, N. A. Moyo, S. Cole, E. Lam, T. Lobry, R. Wolchinsky, A. Lloyd, K. Ward, E. M. Denham, G. S. Besra, N. Veerapen, P. T. Illing, J. P. Vivian, J. M. Raynes, J. Le Nours, , J. Dukes

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

bioRxiv · Jul 17, 2023Cancer Biology

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

M. Koutsakos, A. Reynaldi, W. S. Lee, J. Nguyen, T. Amarasena, G. Taiaroa, P. Kinsella, K. C. Liew, T. Tran, H. E. Kent, H.-X. Tan, L. C. Rowntree, T. H. O. Nguyen, P. Thomas, K. Kedzierska, , J. A. Juno

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

bioRxiv · Dec 19, 2022Immunology

DeepAIR: a deep-learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis

Y. Zhao, B. He, C. Li, Z. Xu, X. Su, J. Rossjohn, J. Song, J. Yao

DeepAIR integrates sequence and 3D structure features of adaptive immune receptors to predict binding affinity and reactivity, outperforming existing methods on multiple tasks.

bioRxiv · Sep 30, 2022Immunology

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.

W. H. Palmer, L. A. Leaton, A. Campos Codo, P. S. Hume, B. Crute, M. Stone, A. van Bokhoven, R. P. Tobin, M. McCarter, W. J. Janssen, J. Roest, S. Zhu, J. Petersen, J. P. Vivian, J. Rossjohn, , P. J. Norman

This study identifies KIR3DL3 expression in T cells, showing it is upregulated by unconventional stimulation and varies by individual genetic variants.

bioRxiv · Aug 17, 2022Immunology

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

P. A. Mudd, A. A. Minervina, M. V. Pogorelyy, J. S. Turner, W. Kim, E. Kalaidina, J. Petersen, A. J. Schmitz, T. Lei, A. Haile, A. M. Kirk, R. C. Mettelman, J. C. Crawford, T. H. O. Nguyen, L. C. Rowntree, , A. Ellebedy

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

bioRxiv · Sep 8, 2021Immunology

Dual TCR-alpha expression on MAIT cells as a potential confounder of TCR interpretation

S. Suliman, L. Kjer-Nielsen, S. Iwany, K. Lopez, L. Loh, K. Kedzierska, T. A. Ocampo, A. Corbett, J. McCluskey, J. Rossjohn, S. Leon, R. Calderon, L. Lecca, M. B. Murray, B. Moody, I. Van Rhijn

The paper identifies dual TCR-alpha expression on MAIT cells as a confounder in TCR interpretation, showing non-TRAV1-2 TCRs do not bind MR1-5-OP-RU tetramer.

bioRxiv · Mar 25, 2021 · PreprintImmunology

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

C. F. Almeida, D. Smith, T.-Y. Cheng, C. Harpur, E. Batleska, T. Nguyen, T. Hilmenyuk, C. V. Nguyen-Robertson, S. J. Reddiex, I. Van Rhijn, J. Rossjohn, A. P. Uldrich, B. Moody, S. J. Williams, D. G. Pellicci, D. I. Godfrey

This study identifies benzofuran sulfonates and small self-lipid antigens as activators of type II NKT cells via CD1d, revealing non-lipidic small molecules that trigger CD1d-restricted NKT cell responses.

bioRxiv · Mar 5, 2021Immunology