L. Loh

Distinct tissue-dependent composition and gene expression of human fetal innate lymphoid cells

This study examines fetal innate lymphoid cells (ILCs) across human tissues, revealing distinct distribution, developmental kinetics, and gene expression profiles, with a novel ILC progenitor identified in the fetal intestine.

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models

This study compares human innate-like T cells (Tinn) with conventional T cells and mouse models, revealing distinct transcriptional programs and developmental pathways.

MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitis.

This study investigates the role of MAIT cells in a genetically diverse mouse model of spontaneous colitis, finding that MAIT cells drive chronic inflammation and colonic pathology.

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.

This study identifies KIR3DL3 expression in T cells, showing it is upregulated by unconventional stimulation and varies by individual genetic variants.

High expression of CD38 and MHC class II on CD8+ T cells during severe influenza disease reflects bystander activation and trogocytosis

This study investigates CD38 and MHC-II co-expression on CD8+ T cells during severe influenza, finding that it reflects bystander activation and trogocytosis from antigen-presenting cells, and is important for memory establishment.

Dual TCR-alpha expression on MAIT cells as a potential confounder of TCR interpretation

The paper identifies dual TCR-alpha expression on MAIT cells as a confounder in TCR interpretation, showing non-TRAV1-2 TCRs do not bind MR1-5-OP-RU tetramer.

Single-cell RNA transcriptomics identifies Hivep3 as essential in regulating the development of innate-like T lymphocytes

A Multiplex Droplet Digital PCR Assay for Quantification of HTLV-1c DNA Proviral Load and T-Cells from Blood and Respiratory Exudates Sampled in a Remote Setting

This study validates a duplex ddPCR assay to quantify HTLV-1c proviral load and T-cells in remote Indigenous Australian samples, comparing results to flow cytometry.

MAIT cells contribute to protection against lethal influenza infection in vivo

This study shows MAIT cells protect against lethal influenza infection by accumulating and being activated early, with their absence increasing mortality in mice.