Cell BiologybioRxiv
GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade
M. F. Walker, J. Zhang, W. Steiner…·B. R. Myers
This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.
DOI 10.1371/journal.pbio.3002685