Author

F. Nagel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

S. Schulz· 4 shared A. Kliewer· 2 shared S. Fritzwanker· 2 shared A. B. Long· 1 shared A. B. Tobin· 1 shared A. Lee· 1 shared A. M. Abdelmalik· 1 shared A. Poddar· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

S. Schulz

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Author profile →

4 papers

Recent·Most cited

Phosphorylation bar-coding of Free Fatty Acid receptor 2 is generated in a tissue-specific manner

N. Barki, L. Jenkins, S. Marsango, D. Dedeo, D. Bolognini, L. Dwomoh, A. M. Abdelmalik, M. Nilsen, M. Stoffels, S. Schulz, F. Nagel, A. B. Tobin, G. Milligan

The paper demonstrates tissue-specific phosphorylation patterns of FFA2 in response to the same agonist in different tissues using transgenic mice and phospho-specific antibodies.

bioRxiv · Sep 1, 2023Cell Biology

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

M. F. Walker, J. Zhang, W. Steiner, P.-I. Ku, J.-F. Zhu, Z. Michaelson, Y.-C. Yen, A. Lee, A. B. Long, M. J. Casey, A. Poddar, I. B. Nelson, C. D. Arveseth, F. Nagel, R. Clough, , B. R. Myers

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

bioRxiv · May 10, 2023Cell Biology

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

J. Kaufmann, N. K. Blum, F. Nagel, A. S. Anna Schuler, J. Drube, C. Degenhart, J. Engel, J. E. Eickhoff, P. Dasgupta, S. Fritzwanker, M. Guastadisegni, C. Schulte, E. Miess-Tanneberg, H. M. Maric, M. Spetea, , S. Schulz

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

bioRxiv · Jul 25, 2022Pharmacology & Toxicology

In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies

S. Fritzwanker, F. Nagel, A. Kliewer, V. Stammer, S. Schulz

This paper demonstrates that phosphatase inhibitors are essential for preserving phosphorylated GPCR states during immunohistochemistry, enabling accurate visualization of drug-induced receptor activation in native tissues.

bioRxiv · Jun 14, 2022Pharmacology & Toxicology