Pharmacology & ToxicologybioRxivPreprint
Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes
J. Wang, A. Casimiro-Garcia, B. G. Johnson…·K. Dower
The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.
DOI 10.1101/2020.12.02.406892