K. Matsuda

Incorporation of 5 methylcytidine alleviates innate immune response to self-amplifying RNA vaccine

This study shows that incorporating 5-methylcytidine into saRNA vaccines reduces innate immune activation and adverse effects while maintaining strong immune responses.

A Tetravalent Dengue Virus-like Particle Vaccine Induces High levels of Neutralizing Antibodies and Inhibits Dengue Replication in Non-Human Primates

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

HOIL-1L deficiency induces cell cycle alteration which causes immaturity of myocyte and fibrogenesis

This study shows HOIL-1L deficiency leads to cell cycle defects and fibrosis in myotubes and cardiomyocytes, contributing to myopathy and dilated cardiomyopathy.

Origami-based growing tube model for reproducing shell shapes

This study uses origami to create physical models of shell shapes based on a mathematical growing tube model, enabling hands-on understanding of shell morphology parameters.

An in vitro microfluidic culture device for peripheral neurotoxicity prediction at low concentration based on deep learning

This paper develops a microfluidic culture device with deep learning for predicting peripheral neurotoxicity at low drug concentrations using neurite morphology analysis.

G307S DNAM-1 mutation exacerbates autoimmune encephalomyelitis via enhancing CD4+ T cell activation

This study shows that the G307S DNAM-1 mutation enhances CD4+ T cell activation and worsens autoimmune encephalomyelitis.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Two structurally different oomycete lipophilic MAMPs induce distinctive plant immune responses.

This study identifies two structurally distinct oomycete MAMPs, ceramides and diacylglycerols, that induce different plant immune responses through unique molecular patterns.

Redundant and specific roles of EGFR ligands in the ERK activation waves during collective cell migration of MDCK cells

The paper investigates the roles of EGFR ligands in ERK activation waves during MDCK cell migration, finding redundancy and specific contributions among the ligands.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

IFN-{lambda}4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression

This study identifies differential MIF receptor expression in GBM MDSC subsets and shows targeting M-MDSCs with ibudilast reduces immune suppression.