Cancer BiologybioRxiv
Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model
H. Eom, K. S. Cho, J. Lee…·M. Steinegger
The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.
DOI 10.1093/nar/gkae1245