E. Armstrong

Biological mechanisms are necessary to improve projections of species range shifts

The paper compares correlative and process-based species distribution models to assess their performance under climate change, finding process-based models more reliable.

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.

Individual dietary amino acid restrictions induce distinct metabolic and chromatin states

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

Developing a safe 15-hour preservation protocol of donor kidneys using normothermic machine perfusion

This study develops a 15-hour normothermic machine perfusion protocol for donor kidneys, showing stable function and no injury.

Potently neutralizing human monoclonal antibodies against the zoonotic pararubulavirus Sosuga virus

The paper identifies potent human monoclonal antibodies against Sosuga virus, revealing epitope diversity and neutralization mechanisms.

Impact of Holocene environmental change on the evolutionary ecology of an Arctic top predator

This study examines how Holocene environmental changes impacted the evolutionary ecology of Greenlandic polar bears using genomics, isotopic analysis, morphometrics, and ecological modeling.

Does oxidative stress shorten telomeres in vivo? A meta-analysis

This meta-analysis examines the link between oxidative stress and telomere dynamics in vivo, finding no overall correlation but significant effects in specific contexts.

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

The paper identifies a rare antibody that targets the SARS-CoV-2 spike trimer interface, disrupting viral entry and providing protection in mice.

Intragenic proviral elements support transcription of defective HIV-1 proviruses

The paper shows defective HIV-1 proviruses can be transcribed via intragenic elements, producing aberrant RNAs that may contribute to inflammation in HIV-positive individuals.

Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates

The paper evaluates variation in germline mutation rate estimates across labs using a standardized pedigree of rhesus macaques, highlighting methodological differences and the need for standardization.

The crucial role of genome-wide genetic variation in conservation

This paper evaluates the feasibility of focusing conservation efforts on functional genetic variation versus genome-wide genetic variation, finding that the latter is more effective in preventing inbreeding depression and loss of adaptive potential.

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

A holobiont view of island biogeography: unraveling patterns driving the nascent diversification of a Hawaiian spider and its microbial associates

This study examines the evolutionary patterns of a Hawaiian spider and its microbial associates across volcanic islands, finding distinct diversification trends among host spiders, endosymbionts, and gut microbiota.

Evolution of herbivory remodels a Drosophila genome

This study examines how the evolution of herbivory in Drosophila species reshaped their genome, particularly in genes related to chemical sensing and detoxification.

Horizontal transfer of prokaryotic cytolethal distending toxin B genes to eukaryotes

The paper reports the horizontal transfer of the cdtB gene, encoding a DNase, from bacteriophages to eukaryotic insect genomes, where it retains DNase activity and may serve as a defensive mechanism against parasitoid wasps.