Author

M. Pedersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Ecology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

S. Foo· 5 shared E. C. Patin· 4 shared K. J. Harrington· 4 shared M. McLaughlin· 4 shared V. Roulstone· 4 shared A. Melcher· 3 shared A. Rullan· 3 shared E. Appleton· 3 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersCancer Biology

S. Foo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

National-scale acoustic monitoring of avian biodiversity and migration

A. Bick, V. Bakkestuen, B. Cretois, B. V. Hillier, J. A. Kalas, M. Pedersen, K. Raja, C. Rosten, M. Somveille, B. Stokke, J. Wiel, S. S. Sethi

This study uses national-scale passive acoustic monitoring to track avian migration patterns and develop species distribution models for three passerine species.

bioRxiv · May 21, 2024Ecology

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

E. Armstrong, M. K. L. Chiu, S. Foo, L. Appleton, P. Nenclares, A. Patrikeev, N. Mohan, M. McLaughlin, G. Bozhanova, J. Hoebart, V. Roulstone, E. C. Patin, M. Pedersen, J. Kyula, F. Errington-Mais, , V. A. Jennings

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.

bioRxiv · Apr 2, 2024Cancer Biology

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

J. Kyula-Currie, V. Roulstone, J. Wright, F. Butera, A. Legrand, R. Elliott, M. McLaughlin, G. Bozhanova, D. B. Krastev, S. Pettitt, T. Tenev, M. T. B. Dillon, S. Foo, E. C. Patin, V. Jennings, , K. J. Harrington

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

bioRxiv · Dec 21, 2023 · PreprintCancer Biology

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent anti-PD-L1- and anti-NKG2A-based adjuvant immunotherapy

E. C. Patin, P. Nenclares, C. Chan Wah Hak, M. T. Dillon, A. Patrikeev, M. McLaughlin, L. Grove, S. Foo, H. Soliman, J. P. Barata, J. Marsden, H. Baldock, V. Roulstone, J. Kyula, A. Burley, , K. J. Harrington

This study combines ATR inhibition with radiotherapy and immune checkpoint blockade to enhance antitumour immunity in HNSCC preclinical models.

bioRxiv · Nov 8, 2023 · PreprintImmunology

Substrate availability and dietary fibre regulate metabolism of tryptophan by human gut microbes

A. K. Sinha, M. F. Laursen, J. E. Brinck, M. L. Rybtke, M. Pedersen, H. M. Roager, T. R. Licht

This study shows that dietary fibre and tryptophan availability influence gut microbial metabolism of tryptophan, shifting production between harmful indole and beneficial ILA/IPA metabolites.

bioRxiv · Jun 5, 2023 · PreprintMicrobiology

Exploring the Spatiotemporal Influence of Climate on American Avian Migration with Random Forests

I. A. Bick, V. Bakkestuen, M. Pedersen, K. Raja, S. S. Sethi

This study uses random forests to predict bird migration patterns based on climate data and eBird surveys, finding that lagged climate features improve predictions in October.

bioRxiv · Mar 27, 2023Ecology

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

V. Roulstone, J. Kyula, J. Wright, L. Yu, A. Barreiro Alonso, M. Melake, J. Choudhary, R. Elliott, C. J. Lord, D. Mansfield, N. Matthews, R. Chauhan, V. Jennings, C. Chan, H. Baldock, , K. J. Harrington

bioRxiv · Sep 28, 2022 · PreprintCancer Biology

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

J. Hassan, E. Appleton, B. Kalfaoglu, M. Pedersen, J. Almeida-Santos, H. Kanemaru, N. Irie, S. Foo, O. Reda, B. J. Y. Tan, I.-m. Okazaki, T. Okazaki, Y. Satou, K. Harrington, A. Melcher, M. Ono

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

bioRxiv · Jul 19, 2022 · PreprintImmunology