Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic metabolism to fuel growth.
S. Kesvari, J. Masson, M. Ferrari-Cestari, L.-G. Bodea, F. Nooru-Mohamed, B. Tse, K. Sokolowski, L. Batoon, O. Patkar, M. Sullivan, H. Ebersbach, C. Stutz, R. Parton, A. Pettit, D. Hume, K. M. Irvine
This study shows that CSF1 increases tissue macrophages and alters systemic metabolism, including glucose uptake and fat mobilization, with reversible effects on liver size and body composition.
bioRxiv · May 17, 2023 · PreprintImmunology