Author

A. Sehgal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 2 Cancer Biology· 1 Ecology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:mouse· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:metabolomics· 2

Frequent Co-Authors

D. A. Hume· 3 shared A. C. Wu· 2 shared A. R. Pettit· 2 shared J.-P. Levesque· 2 shared K. M. Irvine· 2 shared L. Batoon· 2 shared L. J. Raggatt· 2 shared S. Kaur· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

D. A. Hume

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

Y. Zhang, S. B. Noya, Y. Li, F. J. chao, A. Sehgal

This study shows the gut microbiome enhances metabolite cycling in Drosophila, interacting with the circadian clock and diet, with high-protein diets increasing cycling and high-sugar diets suppressing it.

bioRxiv · Feb 29, 2024Microbiology

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells

D. M. Iascone, X. Zhang, P. Bafford, C. Mesaros, Y. Sela, S. Hofbauer, S. L. Zhang, K. Cook, P. Pivarshev, B. Stanger, S. A. Anderson, C. V. Dang, A. Sehgal

This study shows that metabolic activity in cancer cells affects circadian rhythms, with hypermetabolic states linked to weaker circadian oscillations in both mouse and human tumor cells.

bioRxiv · Nov 8, 2023 · PreprintCancer Biology

Intraperitoneal transfer of wild-type bone marrow cells in the Csf1r knockout rat repopulates resident tissue macrophages without contributing to monocytopoiesis.

A. Sehgal, D. Cater-Cusack, S. Keshvari, O. L. Patkar, S. Huang, K. Summers, K. M. Irvine, D. A. Hume

The paper shows that wild-type bone marrow cells can repopulate tissue macrophages in Csf1r knockout rats without contributing to monocytopoiesis.

bioRxiv · Feb 19, 2023 · PreprintImmunology

Circadian Control of Pulmonary Endothelial Signaling occurs via NADPH oxidase 2-NLRP3 pathway

S. Sengupta, Y. Lee, J. Q. Tao, A. Sehgal, S. Chatterjee

This study shows that circadian rhythms in pulmonary endothelial cells are disrupted by LPS through the NOX2-NLRP3 pathway, leading to sustained inflammation.

bioRxiv · Jun 5, 2022Physiology

Circadian regulation of lung repair and regeneration

A. Naik, K. Forrest, Y. Issah, U. Valekunja, A. B. Reddy, E. Hennessy, T. Brooks, A. Babu, M. Morley, G. R. Grant, G. A. FitzGerald, A. Sehgal, G. S. Worthen, D. B. Frank, E. E. Morrisey, S. Sengupta

This study shows that the circadian clock regulates lung repair and regeneration independently of inflammation, identifies the Wnt/β-catenin pathway as a mediator, and links poor circadian rhythms to worse lung infection outcomes.

bioRxiv · Nov 20, 2021Cell Biology

Fragmentation of macrophages during isolation confounds analysis of single cell preparations from mouse hematopoietic tissues

S. M. Millard, O. Heng, K. S. Opperman, A. Sehgal, K. M. Irvine, S. Kaur, K. M. Summers, C. J. Sandrock, A. C. Wu, G. W. Magor, L. Batoon, A. C. Perkins, J. E. Noll, A. C. Zannettino, D. P. Sester, , A. R. Pettit

The paper identifies macrophage fragmentation during isolation as a confounding factor in single-cell analysis of mouse hematopoietic tissues, revealing its impact on marker expression and function.

bioRxiv · Apr 28, 2021Immunology

Stable colony stimulating factor 1 fusion protein treatment increases HSC pool and enhances their mobilisation in mice.

S. Kaur, A. Sehgal, A. C. Wu, S. M. Millard, L. Batoon, M. Ferrari-Cestari, J.-P. Levesque, D. A. Hume, L. J. Raggatt, A. R. Pettit

CSF1-Fc treatment expands the HSC pool and enhances their mobilization in mice, improving transplantation outcomes.

bioRxiv · Sep 13, 2020Cell Biology

Nest records, Nest Site selection of Gyps bengalensis White-rumped Vulture and the role of Feeding Station in Kangra, Himachal Pradesh

A. Sehgal, K. Kumar, R. Rajan, U. Hore

This study records nest sites of White-rumped Vultures in Kangra, Himachal Pradesh, and finds that elevation, aspect, and proximity to feeding stations influence nesting site selection.

bioRxiv · Jul 29, 2020 · PreprintEcology

Fecal microbiota transplantation efficacy for Clostridium difficile infection: A trans-kingdom battle between donor and recipient gut microbiomes

N. Kazemian, M. Ramezankhani, A. Sehgal, F. M. Khalid, A. H. Z. Kalkhoran, A. Narayan, G. K.-S. Wong, D. Kao, S. Pakpour

This study uses metagenomic sequencing and machine learning to show that FMT success depends on donor-recipient microbiome interactions, including specific bacterial and fungal taxa, and ecological repair mechanisms.

bioRxiv · May 27, 2020 · PreprintMicrobiology