M. Sullivan

Generative Adversarial Networks Accurately Reconstruct Pan-Cancer Histology from Pathologic, Genomic, and Radiographic Latent Features

This paper introduces HistoXGAN, a GAN that reconstructs cancer histology from latent features, showing it retains tumor grade, histologic subtype, and gene expression patterns across 29 cancer types.

Cellular mechanotransduction of human osteoblasts in microgravity

This study investigates how microgravity affects human fetal osteoblasts by measuring cell mechanics and signaling changes in space compared to ground controls.

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic metabolism to fuel growth.

This study shows that CSF1 increases tissue macrophages and alters systemic metabolism, including glucose uptake and fat mobilization, with reversible effects on liver size and body composition.

Unraveling the viral dark matter of the rumen microbiome with a new global virome database

The paper creates a rumen virome database (RVD) and identifies 397,180 viral species-level OTUs, improving classification rates and revealing ecosystem impacts of rumen viruses.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Making Strides in Doctoral-Level Career Outcomes Reporting: Surveying the Landscape of Classification and Visualization Methodologies and Creating a Crosswalk Tool

This paper reviews PhD career outcome tracking systems and creates a crosswalk tool to map similarities between taxonomies.

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection

This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.

Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiome.

This study investigates the impact of Giardia infection on gut microbiome structure in dogs and children, finding significant microbiome remodeling associated with infection.

Induction of long-lived potential aestivation states in laboratory An. gambiae mosquitoes

This study induces long-lived aestivation-like states in laboratory Anopheles gambiae mosquitoes by manipulating environmental conditions to extend survival beyond typical lifespan.

Quantifying flight aptitude variation in wild A. gambiae s.l. in order to identify long-distance migrants

The paper quantifies flight aptitude variation in wild Anopheles gambiae s.l. mosquitoes to identify long-distance migrants, finding bi-modal distributions and seasonal increases in flight activity.

Syndecan-1 facilitates breast cancer metastasis to the brain

This study shows that syndecan-1 promotes breast cancer metastasis to the brain by enhancing cell migration across the blood-brain barrier and altering cytokine secretion.

Overview of the SAMPL6 host-guest binding affinity prediction challenge

This paper provides an overview of the SAMPL6 host-guest binding affinity prediction challenge, highlighting methodological improvements and remaining challenges in predicting binding affinities.

Numerous cultivated and uncultivated viruses encode ribosomal proteins

The paper identifies ribosomal proteins encoded by viruses across diverse genomes and metagenomes, challenging the assumption that viruses lack these core translation components.