L. E. McCoy

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

Circulating class-switched spike and RBD-specific memory B cells can outlast detectable neutralising antibodies but are functionally constrained in the elderly.

This study characterizes the B.1.1.7 and Pangolin coronavirus spike proteins, revealing how NTD mutations enhance viral entry and provide insights into SARS-CoV-2 evolution.

This study examines SARS-CoV-2-specific immune responses in people living with HIV on ART, finding comparable antibody and T cell responses to HIV-negative individuals, with T cell magnitude linked to CD4 T cell pool size and CD4:CD8 ratio.

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.

This study reprograms B cells to express HIV-specific BCRs by editing immunoglobulin genes with CRISPR-Cas9, enabling improved anti-HIV neutralizing activity.