Author

D. Peppa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:flow cytometry· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

F. Burns· 3 shared A. Alrubayyi· 2 shared A. Ogbe· 2 shared E. Gea-Mallorqui· 2 shared E. Moreno Cubero· 2 shared E. Touizer· 2 shared J. Kopycinski· 2 shared L. E. McCoy· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

F. Burns

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5 papers

Recent·Most cited

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

S. Sivakumar, A. Jainarayanan, E. Arbe-Barnes, M. N. Leathlobhair, P. K. Sharma, S. Amin, L. Heij, S. Hegde, A. Magen, F. Tucci, B. Sun, S. Wu, N. M. Anand, H. Slawinski, S. Revale, , R. J. M. Bashford-Rogers

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

bioRxiv · Aug 31, 2023 · PreprintImmunology

Attenuated humoral responses in HIV infection after SARS-CoV-2 vaccination are linked to global B cell defects and cellular immune profiles

E. Touizer, A. Alrubbayi, R. Ford, N. Hussain, P. Pereyra Gerber, H.-L. Shum, C. Rees-Spear, L. Muir, E. Gea-Mallorqui, J. Kopycinski, D. Jankovic, C. Pinder, T. A. Fox, I. Williams, C. Mullender, , L. E. McCoy

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

bioRxiv · Nov 11, 2022 · PreprintImmunology

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

A. Alrubayyi, E. Gea-Mallorqui, E. Touizer, D. Hameiri-Bowen, J. Kopycinski, B. Charlton, N. Fisher-Pearson, L. Muir, A. Rosa, C. Roustan, C. Earl, P. Cherepanov, P. Pellegrino, L. Waters, F. Burns, , D. Peppa

This study examines SARS-CoV-2-specific immune responses in people living with HIV on ART, finding comparable antibody and T cell responses to HIV-negative individuals, with T cell magnitude linked to CD4 T cell pool size and CD4:CD8 ratio.

bioRxiv · Feb 15, 2021Immunology

IL-15 re-programming compensates for NK cell mitochondrial dysfunction in HIV-1 infection

E. Moreno Cubero, S. Balint, A. Alrubayyi, A. Ogbe, R. Matthews, F. Burns, S. Rowland Jones, P. Borrow, A. Schurich, M. Dustin, D. Peppa

This study shows that IL-15 treatment improves NK cell function in HIV-1 infection by enhancing mTORC1 activity and compensating for mitochondrial dysfunction.

bioRxiv · Oct 21, 2019 · PreprintImmunology

Subordinate effect of -21M HLA-B dimorphism on NK cell repertoire diversity and function in HIV-1 infected individuals of African origin

E. Moreno Cubero, A. Ogbe, M. S. Cohen, B. F. Haynes, P. Borrow, D. Peppa

This study examines the effect of HLA-B -21M dimorphism on NK cell diversity and function in HIV-1/HCMV co-infected African individuals, finding no significant correlation with HLA-E abundance or functional advantage.

bioRxiv · Sep 30, 2019Immunology