Author

C. Rees-Spear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. E. McCoy· 4 shared L. Muir· 4 shared K. J. Doores· 3 shared C. Roustan· 2 shared E. Touizer· 2 shared P. Cherepanov· 2 shared R. K. Gupta· 2 shared A. Alrubbayi· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

L. E. McCoy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

S. Griffith, L. Muir, O. Suchanek, J. Hope, C. Pade, J. M. Gibbons, Z. K. Tuong, A. Fung, E. Touizer, C. Rees-Spear, A. Nans, C. Roustan, Y. Alguel, D. Fink, C. Orkin, , L. E. McCoy

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

bioRxiv · Feb 5, 2024 · PreprintMicrobiology

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

L. D. W. King, D. Pulido, J. R. Barrett, H. Davies, D. Quinkert, A. M. Lias, S. E. Silk, D. J. Pattinson, A. Diouf, B. G. Williams, K. McHugh, A. Rodrigues, C. A. Rigby, V. Strazza, J. Suurbaar, , S. J. Draper

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

bioRxiv · Jan 4, 2024Immunology

Attenuated humoral responses in HIV infection after SARS-CoV-2 vaccination are linked to global B cell defects and cellular immune profiles

E. Touizer, A. Alrubbayi, R. Ford, N. Hussain, P. Pereyra Gerber, H.-L. Shum, C. Rees-Spear, L. Muir, E. Gea-Mallorqui, J. Kopycinski, D. Jankovic, C. Pinder, T. A. Fox, I. Williams, C. Mullender, , L. E. McCoy

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

bioRxiv · Nov 11, 2022 · PreprintImmunology

SARS-CoV-2-specific memory B cells can persist in the elderly despite loss of neutralising antibodies

A. Jeffery-Smith, A. R. Burton, S. Lens, C. Rees-Spear, M. Patel, R. Gopal, L. Muir, F. Aiano, K. J. Doores, J. Y. Chow, S. N. Ladhani, M. Zambon, L. E. McCoy, M. K. Maini

Circulating class-switched spike and RBD-specific memory B cells can outlast detectable neutralising antibodies but are functionally constrained in the elderly.

bioRxiv · May 30, 2021 · PreprintImmunology

The impact of Spike mutations on SARS-CoV-2 neutralization

C. Rees-Spear, L. Muir, S. A. Griffith, J. Heaney, Y. Aldon, J. Snitselaar, P. Thomas, C. Graham, J. Seow, N. Lee, A. Rosa, C. Roustan, C. F. Houlihan, R. W. Sanders, R. K. Gupta, , L. E. McCoy

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

bioRxiv · Jan 15, 2021 · PreprintImmunology