Lac-Phe mediates the anti-obesity effect of metformin
S. Xiao, V. L. Li, X. Lyu, X. Chen, W. Wei, F. Abbasi, J. Knowles, S. Deng, G. Tiwari, X. Shi, S. Deng, L. Farrell, Z.-Z. Chen, K. Taylor, X. Guo, , J. Z. Long
This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.
bioRxiv · Nov 2, 2023 · PreprintPhysiology