K. Dave

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

This study validates ferroptosis in canine cancer cells, showing similar responses to human cells, supporting dogs as a model for developing ferroptosis-based cancer therapies.

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

This paper shows that medium-to-large extracellular vesicles (m/lEVs) protect brain endothelial cells by transferring mitochondria and reducing brain infarct sizes in a mouse stroke model.

Fusion of the N-terminal 119 amino acids with the RelA-CTD renders its growth inhibitory effects (p)ppGpp-dependent

This study shows that the N-terminal 119 amino acids of RelA regulate its CTD function in a (p)ppGpp-dependent manner, affecting bacterial growth.

Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growth

This study shows that deleting the Myc super-enhancer region in mice reduces Myc expression and tumor susceptibility without overt phenotypes, suggesting therapeutic potential for targeting this element in cancer.