Author

L. Goo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

L. M. Levoir· 3 shared M. Contreras· 3 shared A. M. Sanz· 2 shared B. J. Doranz· 2 shared C. H. Cartwright-Acar· 2 shared C. Kikawa· 2 shared E. Davidson· 2 shared F. Rosso· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMicrobiology

L. M. Levoir

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

J. Lubow, L. M. Levoir, D. K. Ralph, L. Belmont, M. Contreras, C. H. Cartwright-Acar, C. Kikawa, S. Kannan, E. Davidson, B. J. Doranz, V. Duran, D. E. Sanchez, A. M. Sanz, F. Rosso, S. Einav, , L. Goo

The paper uses single-cell transcriptomics to identify new broadly neutralizing antibodies against flaviviruses, including an IgA1 isotype with unique neutralizing properties.

PLOS Pathogens · Oct 9, 2023Peer-reviewedMicrobiology

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies

L. Goo, C. Kikawa, C. H. Cartwright-Acar, J. B. Stuart, M. Contreras, L. M. Levoir, M. J. Evans, J. D. Bloom

This study identifies how single mutations in Zika virus envelope protein affect neutralization by broadly and narrowly specific antibodies, finding that broad antibodies are harder to escape.

bioRxiv · Sep 13, 2023Microbiology

Defining the impact of flavivirus envelope protein glycosylation on sensitivity to broadly neutralizing antibodies

M. Contreras, J. B. Stuart, L. M. Levoir, L. Belmont, L. Goo

This paper investigates how glycosylation of flavivirus envelope proteins affects neutralization by broadly neutralizing antibodies, finding that glycosylation modulates antibody potency in unexpected ways.

bioRxiv · Jun 20, 2023 · PreprintMicrobiology

Norstictic acid is a selective allosteric transcriptional regulator

J. M. Garlick, S. M. Sturlis, P. A. Bruno, J. A. Yates, A. Peiffer, Y. Liu, L. Goo, L. Bao, S. De Salle, G. Tamayo-Castillo, C. L. Brooks, S. D. Merajver, A. K. Mapp

This study identifies norstictic acid as a selective allosteric inhibitor of Med25-mediated transcriptional interactions, showing its effect in vitro and in a breast cancer model.

bioRxiv · Mar 26, 2021Biochemistry

Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

N. D. Durham, A. Agrawal, E. Waltari, D. Croote, F. Zanini, M. Fouch, E. Davidson, O. Smith, E. Carabajal, J. E. Pak, B. J. Doranz, M. Robinson, A. M. Sanz, L. L. Albornoz, F. Rosso, , L. Goo

The paper identifies two broadly neutralizing antibodies against dengue virus through single B cell transcriptomics and characterizes their epitopes and evolutionary pathways.

bioRxiv · Oct 2, 2019Microbiology