Author

J. B. Stuart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Singapuri· 2 shared J. Usachenko· 2 shared J. Watanabe· 2 shared K. K. A. Van Rompay· 2 shared L. Goo· 2 shared L. L. Coffey· 2 shared L. M. Levoir· 2 shared M. Contreras· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

A. Singapuri

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies

L. Goo, C. Kikawa, C. H. Cartwright-Acar, J. B. Stuart, M. Contreras, L. M. Levoir, M. J. Evans, J. D. Bloom

This study identifies how single mutations in Zika virus envelope protein affect neutralization by broadly and narrowly specific antibodies, finding that broad antibodies are harder to escape.

bioRxiv · Sep 13, 2023Microbiology

Defining the impact of flavivirus envelope protein glycosylation on sensitivity to broadly neutralizing antibodies

M. Contreras, J. B. Stuart, L. M. Levoir, L. Belmont, L. Goo

This paper investigates how glycosylation of flavivirus envelope proteins affects neutralization by broadly neutralizing antibodies, finding that glycosylation modulates antibody potency in unexpected ways.

bioRxiv · Jun 20, 2023 · PreprintMicrobiology

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectors

D. Lemos, J. B. Stuart, W. Louie, A. Singapuri, A. L. Ramirez, J. Watanabe, J. Usachenko, R. Keesler, C. Sanchez-San Martin, T. Li, C. Martyn, G. Oliveira, S. Saraf, N. D. Grubaugh, K. Andersen, , L. L. Coffey

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

bioRxiv · Aug 11, 2020Microbiology

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

K. K. A. Van Rompay, L. L. Coffey, T. Kapoor, A. Gazumyan, R. I. Keesler, A. Jurado, A. Peace, M. Agudelo, J. Watanabe, J. Usachenko, A. Singapuri, R. Immareddy, A. Ardeshir, J. B. Stuart, S. Bournazos, , D. F. Robbiani

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

bioRxiv · Jan 31, 2020Immunology