L. Hoffmann

Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration

This study shows that Ena/VASP proteins are essential for dendritic cell migration by coordinating actin nucleation pathways through interactions with formin mDia1 and the WAVE complex.

Archival influenza virus genomes from Europe reveal genomic and phenotypic variability during the 1918 pandemic

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

Photoperiod Sensitive Energy Sorghum Responses to Environmental and Nitrogen Variabilities

This study evaluates biomass yield and feedstock quality of photoperiod-sensitive sorghum hybrids under varying nitrogen inputs and environments, finding higher yields in temperate regions with lower nitrogen requirements.