Author

A. Bahrami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Shelat· 2 shared E. Stewart· 2 shared M. Clay· 2 shared S. Federico· 2 shared A. H. Bahrami· 1 shared A. Naranjo· 1 shared A. Pappo· 1 shared A. Sykes· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

A. Shelat

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular mechanisms and energetics of lipid droplet formation and directional budding

F. Kazemisabet, A. Bahrami, R. Ghosh, B. Rozycki, A. H. Bahrami

This study uses simulations to show lipid droplet (LD) formation and budding are governed by ER and LD tensions, with budding being energetically neutral and tension-independent.

bioRxiv · Dec 4, 2023 · PreprintBiophysics

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

L.-A. Van de Velde, E. K. Allen, J. C. Crawford, T. L. Wilson, C. S. Guy, M. Russier, L. Zeitler, A. Bahrami, D. Finkelstein, S. Pelletier, S. Schultz-Cherry, P. G. Thomas, P. J. Murray

This study identifies unconventional CD4 T cells and myeloid amino acid metabolism as critical for neuroblastoma formation using a mouse model and spatial transcriptomics.

bioRxiv · Feb 8, 2021Cancer Biology

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

J. Gartrell, M. Mellado-Lagarde, N. Martinez, M. Clay, A. Bahrami, N. Sahr, A. Sykes, K. Blankenship, L. Hoffmann, J. Xie, H. P. Cho, N. Twarog, M. Connelly, K.-K. Yan, J. Yu, , A. Shelat

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

bioRxiv · Nov 5, 2020 · PreprintCancer Biology

MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma

M. Zeineldin, S. Federico, X. Chen, Y. Fan, B. Xu, E. Stewart, X. Zhou, J. Jeon, L. Griffiths, J. Easton, H. Mulder, D. Yergeau, Y. Liu, J. Wu, C. Van Ryn, , M. Dyer

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

bioRxiv · Jul 29, 2018Cancer Biology