Author

S. Federico

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Bahrami· 2 shared A. Shelat· 2 shared E. Stewart· 2 shared J. Jeon· 2 shared K. Blankenship· 2 shared L. Hoffmann· 2 shared M. Clay· 2 shared X. Zhou· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. Bahrami

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)

K. Blankenship, T.-C. Chang, Y. Fan, B. Gordon, W. C. Wright, M. Kieffer, A. Karlstrom, J. Jeon, A. Patel, J. Dapper, W. V. Caufield, B. B. Freeman, S. Federico, M. R. Clay, G. G. Wu, , E. A. Stewart

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

bioRxiv · Jul 22, 2024 · PreprintCancer Biology

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation

M. T. Bertran, R. Walmsley, T. F. M. Cummings, I. Aramburu, D. J. Benton, J. Assalaarachchi, M. Chasampalioti, T. Swanton, D. Joshi, S. Federico, H. Okkenhaug, L. Yu, D. Oxley, S. Walker, V. Papayannopoulos, , L. J. Walport

The paper develops cyclic peptide modulators of PADI4 and reveals their mechanism of action and cellular activity.

bioRxiv · Dec 12, 2023Biochemistry

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

J. Gartrell, M. Mellado-Lagarde, N. Martinez, M. Clay, A. Bahrami, N. Sahr, A. Sykes, K. Blankenship, L. Hoffmann, J. Xie, H. P. Cho, N. Twarog, M. Connelly, K.-K. Yan, J. Yu, , A. Shelat

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

bioRxiv · Nov 5, 2020 · PreprintCancer Biology

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

O. Belan, C. Barroso, A. Kaczmarczyk, R. Anand, S. Federico, N. O'Reilly, M. D. Newton, E. Maeots, R. I. Enchev, E. Martinez-Perez, D. S. Rueda, S. J. Boulton

The paper uses single-molecule imaging to show how BRC-2 and RFS-1/RIP-1 mediate RAD-51 filament nucleation and growth during homologous recombination.

bioRxiv · Nov 5, 2020Biophysics

Global profiling of myristoylation in Toxoplasma gondii reveals key roles for lipidation in CDPK1 and MIC7 function

M. Broncel, C. Dominicus, A. Hunt, B. A. Wallbank, S. Federico, J. C. Young, M. Treeck

The paper identifies 65 myristoylated proteins in Toxoplasma gondii, highlighting roles for myristoylation in CDPK1 signaling and MIC7 function during host cell invasion.

bioRxiv · Jul 30, 2019 · PreprintMicrobiology

MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma

M. Zeineldin, S. Federico, X. Chen, Y. Fan, B. Xu, E. Stewart, X. Zhou, J. Jeon, L. Griffiths, J. Easton, H. Mulder, D. Yergeau, Y. Liu, J. Wu, C. Van Ryn, , M. Dyer

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

bioRxiv · Jul 29, 2018Cancer Biology