Author

T.-C. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Bioengineering· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

G. Wu· 3 shared B. A. Orr· 2 shared D. Finkelstein· 2 shared H. Jin· 2 shared J. H. Landmann· 2 shared J. M. Warrington· 2 shared J. Wu· 2 shared M. E. Selli· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

G. Wu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Rational protein engineering to enhance MHC-independent T cell receptors

J. Chang, J. H. Landmann, T.-C. Chang, Y. Tenzin, J. M. Warrington, M. E. Selli, J. Ritchey, Y.-S. Hsu, M. Slade, D. K. Gupta, J. F. DiPersio, N. Singh

The paper designs MHC-independent T cell receptors (miTCRs) to enhance cancer immunotherapy by improving receptor stability and function through structural modeling and iterative sequence modifications.

bioRxiv · Feb 22, 2024Immunology

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

A. G. Patel, O. Ashenberg, N. B. Collins, A. Segerstolpe, S. Jiang, M. Slyper, X. Huang, C. Caraccio, H. Jin, H. Sheppard, K. Xu, T.-C. Chang, B. A. Orr, A. Shirinifard, R. H. Chapple, , S. J. Rodig

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

bioRxiv · Jan 7, 2024 · PreprintCancer Biology

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

Z. Yang, B. A. Johnson, V. A. Meliopoulos, X. Ju, P. Zhang, M. P. Hughes, J. Wu, K. P. Koreski, T.-C. Chang, G. Wu, J. Hixon, J. Duffner, K. Wong, R. Lemieux, K. G. Lokugamage, , J. P. Taylor

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

bioRxiv · Jun 29, 2023 · PreprintCell Biology

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

J. YANG, C. M. Jablonowski, W. Quarni, S. Singh, H. Tan, D. H. Bostanthirige, H. Jin, J. Fang, T.-C. Chang, D. Finkelstein, J.-H. Cho, D. Hu, V. Pagala, S. M. Sakurada, S. M. Pruett-Miller, , G. Wu

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

bioRxiv · Jun 26, 2023Cancer Biology

Video-rate three-photon imaging in deep Drosophila brain based on a single Cr:forsterite oscillator

L.-T. Chou, S.-H. Wu, H.-H. Hung, J.-C. Jang, C.-M. Chen, T.-C. Chang, W.-Z. Lin, L.-A. Chu, C.-K. Sun, F. X. Kartner, A. A. Ivanov, S.-W. Chu, S.-H. Chia

This paper demonstrates 30-Hz three-photon imaging in Drosophila brains using a Cr:forsterite oscillator, showing improved signal-to-background ratio and calcium imaging capabilities.

bioRxiv · Mar 23, 2023 · PreprintBioengineering

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

M. E. Selli, J. H. Landmann, M. Terekhova, J. Lattin, A. Heard, Y.-S. Hsu, T.-C. Chang, J. M. Warrington, H. Ha, N. Kingston, G. Hogg, M. Slade, M. M. Berrien-Elliot, M. Foster, S. Kersting-Schadek, , N. Singh

This study identifies that chronic activation of 41BB-based CARs leads to a novel T cell dysfunction state, distinct from exhaustion, which can be mitigated by disrupting FOXO3.

bioRxiv · Jan 26, 2023 · PreprintImmunology

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

C. McLeod, A. M. Gout, X. Zhou, D. Rahbarinia, A. Thrasher, S. Newman, K. Birch, M. Macias, D. Finkelstein, J. Sunny, R. Mudunuri, B. A. Orr, M. Treadway, B. Davidson, T. Ard, , Z Wang

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

bioRxiv · Aug 24, 2020Cancer Biology

Allergic inflammation hinders synergistic viral-bacterial co-infection in C57BL/6 mice

K. LeMessurier, A. Iverson, T.-C. Chang, M. Palipane, P. Vogel, J. Rosch, A. Samarasinghe

This study shows that allergic inflammation in mice reduces severity of viral-bacterial co-infection by altering the lung microbiome and immune response.

bioRxiv · Feb 15, 2019 · PreprintPathology