Author

L. M. Orchard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:plant (other)· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

H. J. Painter· 2 shared M. Llinas· 2 shared A. B. Vaidya· 1 shared B. F. C. Kafsack· 1 shared C. Luck· 1 shared D. Patel· 1 shared J. M. Morrisey· 1 shared J. M. Santos· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

H. J. Painter

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Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivOct 27, 2020

The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation

S. Singh, J. M. Santos, L. M. Orchard…·M. Llinas

This study identifies PfAP2-G2 as a critical transcription factor for Plasmodium falciparum gametocyte maturation, showing it regulates gene expression and interacts with chromatin remodeling proteins.

DOI 10.1111/mmi.14676

humanDNA methylation

𝕏 PostBluesky

MicrobiologybioRxivPreprintOct 26, 2020

The essential transcriptional regulator HDP1 drives expansion of the inner membrane complex during early sexual differentiation of malaria parasites.

R. Campelo Morillo, X. Tong, W. Xie…·B. F. C. Kafsack

This study identifies HDP1 as a transcriptional regulator essential for upregulating inner membrane complex genes during early gametocytogenesis in Plasmodium falciparum.

DOI 10.1101/2020.10.26.352583

plant (other)DNA methylation

𝕏 PostBluesky

MicrobiologybioRxivOct 8, 2020

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather…·M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

DOI 10.1128/aac.02143-20

plant (other)whole-genome sequencing

𝕏 PostBluesky