Author

L. Muchene

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Organism:rat· 1 Organism:zebrafish· 1

Frequent Co-Authors

H. Schuitemaker· 4 shared F. Wegmann· 3 shared J. Custers· 3 shared Y. Choi· 3 shared A. Izquierdo Gil· 2 shared D. H. Barouch· 2 shared E. J. Snijder· 2 shared E. Kourkouta· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

H. Schuitemaker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Immunogenicity of an Ad26-based SARS-CoV-2 Omicron Vaccine in Naïve Mice and SARS-CoV-2 Spike Pre-immune Hamsters

M. Swart, A. de Wilde, S. Schmit-Tillemans, J. Verspuij, C. Daal, Y. Choi, A. Perkasa, E. Kourkouta, I. Tahiri, M. Mulders, A. I. Gil, L. Muchene, J. Juraszek, J. Vellinga, J. Custers, , R. Zahn

This study evaluates an Ad26-based Omicron spike vaccine in mice and pre-immune hamsters, showing it induces neutralizing antibodies against Omicron and Delta variants.

bioRxiv · Mar 4, 2022 · PreprintImmunology

Ad26.COV2.S elicited neutralizing activity against Delta and other SARS-CoV-2 variants of concern

M. Jongeneelen, K. Kaszas, D. Veldman, J. Huizingh, R. van der Vlugt, T. Schouten, D. Zuijdgeest, T. Uil, G. van Roey, N. Guimera, M. Navis, R. Bos, M. Le Gars, J. Sadoff, L. Muchene, , B. Brandenburg

This study evaluates the neutralizing activity of Ad26.COV2.S vaccine sera against SARS-CoV-2 variants, finding reduced effectiveness against Beta and Gamma but less reduction against Delta.

bioRxiv · Jul 1, 2021 · PreprintImmunology

Ad26.COV2.S-elicited immunity protects against G614 spike variant SARS-CoV-2 infection in Syrian hamsters and does not enhance respiratory disease in challenged animals with breakthrough infection after sub-optimal vaccine dosing

J. E. M. van der Lubbe, S. K. Rosendahl Huber, A. Vijayan, L. Dekking, E. van Huizen, J. Vreugdenhil, Y. Choi, M. R. M. Baert, K. Feddes-de Boer, A. Izquierdo Gil, M. van Heerden, T. J. Dalebout, S. K. Myeni, M. Kikkert, E. J. Snijder, , F. Wegmann

This study shows that a single dose of Ad26.COV2.S vaccine protects Syrian hamsters from G614 SARS-CoV-2 infection and prevents VAERD even with suboptimal immunity.

bioRxiv · Jan 8, 2021 · PreprintImmunology

Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques

L. Solforosi, H. Kuipers, S. K. Rosendahl Huber, J. E. M. van der Lubbe, L. Dekking, D. N. Czapska-Casey, A. Izquierdo Gil, M. Baert, J. Drijver, J. Vaneman, E. van Huizen, Y. Choi, J. Vreugdenhil, S. Kroos, A. H. de Wilde, , R. C. Zahn

This study evaluates one- and two-dose regimens of the Ad26.COV2.S vaccine in rhesus macaques, showing higher antibody responses with two doses and protection against SARS-CoV-2 in aged animals.

bioRxiv · Nov 17, 2020Immunology