Author

L. Ortiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metagenomics· 1 Organism:rat· 1 Research Focus:variant calling· 1

Frequent Co-Authors

D. R. Perez· 2 shared G. Geiger· 2 shared A. Claudel· 1 shared A. de la Barra· 1 shared A. G. Schijman· 1 shared A. S. Gonzalez-Reiche· 1 shared B. Seibert· 1 shared C. Alonso-Vega· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEvolutionary Biology

D. R. Perez

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Independent evolution of influenza A virus H1N1 in pigs in Guatemala

L. Ortiz, G. Geiger, L. Ferreri, D. Moran, D. Alvarez, A. S. Gonzalez-Reiche, D. Mendez, D. S. Rajao, C. Cordon-Rosales, D. R. Perez

The paper identifies independent evolution of H1N1 influenza A viruses in Guatemalan pigs, showing distinct amino acid signatures and genetic lineage from other Central American H1N1 pdm09 viruses.

bioRxiv · Jul 21, 2022 · PreprintEvolutionary Biology

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

B. Seibert, C. J. Caceres, S. Carnaccini, S. Cardenas-Garcia, L. C. Gay, L. Ortiz, G. Geiger, D. S. de Souza Rajao, E. Ottesen, D. R. Perez

This study investigates SARS-CoV-2 infection in aged Golden Syrian hamsters, revealing microbiome dysbiosis and pathobiological changes similar to severe COVID-19 patients.

bioRxiv · Jul 13, 2022Microbiology

Editing of the TRIM5 gene decreases the permissiveness of human T lymphocytic cells to HIV-1

K. Desaulniers, L. Ortiz, C. Dufour, A. Claudel, M. B. Plourde, N. Merindol, L. Berthoux

This study edits the TRIM5 gene in human T cells to restrict HIV-1 infection, showing biallelic modification is needed for significant inhibition.

bioRxiv · Dec 7, 2020Microbiology

Real Time PCR for the Evaluation of Treatment Response in Clinical Trials of Adult Chronic Chagas Disease: Usefulness of Serial Blood Sampling and qPCR Replicates.

R. Parrado, J. C. Ramirez, A. de la Barra, C. Alonso-Vega, N. A. Juiz, L. Ortiz, D. Illanes, F. Torrico, J. Gascon, F. Alves, L. Flevaud, L. Garcia, A. G. Schijman, I. Ribeiro

This paper evaluates serial blood sampling and qPCR replicates to improve PCR sensitivity for detecting treatment response in Chagas disease trials.

bioRxiv · Jun 11, 2018Microbiology