Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread
F. Pahmeier, S. R. Monticelli, X. Feng, C. K. Hjorth, A. Wang, A. I. Kuehne, R. R. Bakken, T. G. Batchelor, S. E. Lee, M. Middlecamp, L. Stuart, D. M. Abelson, J. S. McLellan, S. B. Biering, A. S. Herbert, , E. Harris
This study identifies GP38 as a viral toxin causing vascular leak and shows that specific GP38-targeting antibodies block this effect in vitro and in vivo.
bioRxiv · May 23, 2024Microbiology