L. Schlicker

The gut microbiome-linked long chain fatty acid stearate suppresses colorectal cancer

This study shows that the ketogenic diet reduces colorectal tumors in mice by altering the gut microbiome to increase stearic acid, which suppresses cancer cell growth and immune responses.

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer cells

This paper introduces 13C-SpaceM, a method for spatial single-cell isotope tracing of de novo fatty acid synthesis in cancer cells, revealing metabolic heterogeneity in liver and glioma tissues.

Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

This study shows cancer-associated fibroblasts enhance drug resistance in ALK-driven lung adenocarcinoma by promoting lipid biosynthesis and suppressing lipid peroxidation through AKT signaling.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

c-Myc plays a key role in IFN-γ induced persistence of Chlamydia trachomatis

This study shows that IFN-γ induces Chlamydia persistence by depleting c-Myc, which is regulated by the PI3K-GSK3β axis and L-tryptophan levels, challenging the IDO depletion hypothesis.