Author

T. de Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. J. Mentzer· 1 shared A. Kearns· 1 shared A. McMichael· 1 shared A. Meijer· 1 shared B. Foley· 1 shared B. Korber· 1 shared B. Lindsey· 1 shared B. M. Kessler· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperImmunology

A. J. Mentzer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

T. Dong, Y. Peng, A. J. Mentzer, G. Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, L. Turtle, T. Rostron, K. Subramaniam, P. Thomson, P. Zhang, C. Dold, J. Ratcliff, , Lopez-C

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

bioRxiv · Jun 5, 2020Immunology

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

B. Korber, W. Fischer, S. G. Gnanakaran, H. Yoon, J. Theiler, W. Abfalterer, B. Foley, E. E. Giorgi, T. Bhattacharya, M. D. Parker, D. G. Partridge, C. M. Evans, T. de Silva, C. C. LaBranche, D. C. Montefiori, Sheffield COVID-19 Genomics Group

The paper develops a pipeline to track SARS-CoV-2 mutations in the Spike protein, identifying D614G as a rapidly spreading mutation with potential implications for transmission and immune evasion.

bioRxiv · Apr 29, 2020Evolutionary Biology

The Consequences of Egg Adaptation in the H3N2 Component to the Immunogenicity of Live Attenuated Influenza Vaccine

D. H. Goldhill, B. Lindsey, R. Kugathasan, Z. F. Garza, Y. J. Jagne, H. J. Sallah, G. Goderski, S. van Tol, K. Höschler, A. Meijer, W. S. Barclay, T. de Silva

This study examines how egg adaptation of the H3N2 influenza vaccine strain affects antibody responses in children, finding higher seroconversion rates to the adapted strain but differential mucosal IgA responses based on prior serostatus.

bioRxiv · Nov 12, 2019 · PreprintImmunology

Genomic and epidemiological evidence of a dominant Panton-Valentine leucocidin-positive Methicillin Resistant Staphylococcus aureus lineage in Sri Lanka with spread to the United Kingdom and Australia

S. M. McTavish, S. J. Snow, E. C. Cook, B. Pichon, S. Coleman, G. Coombs, S. Pang, C. Arias, L. Diaz, E. Boldock, S. Davies, M. Udukala, A. Kearns, S. Siribaddana, T. de Silva

The paper conducts genomic analysis of MRSA in Sri Lanka, identifying a dominant PVL-positive ST5-MRSA-IVc lineage that spreads internationally.

bioRxiv · Jan 17, 2019Microbiology

LOW-BIAS RNA SEQUENCING OF THE HIV-2 GENOME FROM BLOOD PLASMA

K. L. James, T. de Silva, K. Brown, H. Whittle, S. Taylor, G. McVean, J. Esbjörnsson, S. Rowland-Jones

This study uses RNA-Seq without PCR amplification to sequence the HIV-2 genome from plasma samples, revealing low genetic diversity in the vpx gene.

bioRxiv · May 10, 2018Microbiology