Author

M. A. Baker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 5 Organism:E. coli· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

P. Ridone· 6 shared T. Ishida· 3 shared Y. Sowa· 3 shared A. Lin· 2 shared J. P. Gurung· 2 shared M. I. Islam· 2 shared N. J. Matzke· 2 shared A. Abbas· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersMicrobiology

P. Ridone

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Hybrid Exb/Mot stators require substitutions distant from the chimeric pore to power flagellar rotation

P. Ridone, M. A. Baker

The paper designs and tests chimeric ion-powered rotary motors (IRMs) by combining components from different bacterial systems, showing that functional improvements require substitutions outside the hybrid pore region.

bioRxiv · Mar 12, 2024Microbiology

Tuning the stator subunit of the flagellar motor with coiled-coil engineering.

P. Ridone, D. L. Winter, M. A. Baker

The paper models the MotB dimer stability and conformational dynamics in the flagellar motor using coiled-coil engineering and free energy calculations, identifying three stable states and correlating them with motility.

bioRxiv · Mar 5, 2023Microbiology

Microbial stir bars: light activated rotation of tethered bacterial cells to enhance mixing in stagnant fluids.

J. P. Gurung, M. N. Kashani, C. M. de Silva, M. A. Baker

The paper demonstrates light-activated rotation of bacterial cells to enhance mixing in microfluidic devices by generating micro-vortices.

bioRxiv · Jan 26, 2023Microbiology

Ancestral reconstruction of the MotA stator subunit reveals that conserved residues far from the pore are required to drive flagellar motility

M. I. Islam, P. Ridone, A. Lin, K. A. Michie, N. J. Matzke, G. K. Hochberg, M. A. Baker

This study uses ancestral sequence reconstruction to identify conserved residues in MotA essential for flagellar motility across different bacterial species.

bioRxiv · Oct 17, 2022Microbiology

Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types

M. I. Islam, J. Bae, T. Ishida, P. Ridone, J. Lin, M. J. Kelso, Y. Sowa, B. J. Buckley, M. A. Baker

This paper identifies two amiloride derivatives that inhibit bacterial motility across multiple strains and stator types, including both Na+ and H+ powered motors.

bioRxiv · Apr 13, 2021Microbiology

The rapid evolution of flagellar ion-selectivity in experimental populations of E. coli

P. Ridone, T. Ishida, A. Lin, D. T. Humphreys, E. Giannoulatou, Y. Sowa, M. A. Baker

The paper shows that E. coli can rapidly revert a CRISPR-induced Na+-powered flagellar motor to H+-powered by evolving new mutations, revealing adaptability and modularity of the motor complex.

bioRxiv · Jan 26, 2021Microbiology

Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics.

J. P. Gurung, M. Navvab Kashani, S. Agarwal, G. Peralta, M. Gel, M. A. Baker

The paper develops a low-cost microfluidic system to separate and enrich sodium-motile bacteria by varying ionic media, achieving eight-fold enrichment of motile populations.

bioRxiv · Nov 24, 2020Microbiology

Binding of DNA origami to lipids: maximising yield and switching via strand-displacement

J. K. D. Singh, E. Darley, P. Ridone, J. P. Gaston, A. Abbas, S. F. Wickham, M. A. Baker

This study identifies optimal conditions for DNA-lipid binding and strand-displacement switching, showing that cholesterol content, DNA structure, and ionic strength affect binding yield and control.

bioRxiv · Jun 1, 2020 · PreprintBiophysics

Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region.

T. Ishida, R. Ito, J. Clark, N. J. Matzke, Y. Sowa, M. A. Baker

The paper identifies mutations in the sodium-powered bacterial flagellar motor stator PotB that confer resistance to phenamil, showing that mutations near the peptidoglycan-binding region enable motor function in the presence of the inhibitor.

bioRxiv · Mar 18, 2019Microbiology