A. Abbas

Klf9 plays a critical role in GR dependent metabolic adaptations in cardiomyocytes

This study identifies Klf9 as a critical mediator of GR-dependent metabolic adaptations in cardiomyocytes through genomic and transcriptomic analyses.

Responses of Agricultural plants to Lithium pollution: Trends, Meta-Analysis, and Perspectives

This study conducts a meta-analysis of lithium's effects on plants, finding varied toxic responses based on exposure medium, source, and concentration.

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

A loss-of-function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition

This study investigates how a cysteine mutation in fibulin-3 (C55R) disrupts its structure and function, leading to altered extracellular matrix composition and impaired ECM remodeling.

Intermittent KHz-frequency electrical stimulation selectively engages small unmyelinated vagal afferents

This study identifies intermittent KHz-frequency electrical stimulation (KES) as a method to selectively engage small unmyelinated vagal C-afferents in rats and mice.

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

An implant for long-term cervical vagus nerve stimulation in mice

This paper develops a long-term vagus nerve stimulation implant in mice and demonstrates its effectiveness in reducing inflammation over 4 weeks.

Binding of DNA origami to lipids: maximising yield and switching via strand-displacement

This study identifies optimal conditions for DNA-lipid binding and strand-displacement switching, showing that cholesterol content, DNA structure, and ionic strength affect binding yield and control.

Phytochrome light receptors control metabolic flux, and their action during seedling development sets the trajectory for biomass production

This study shows that phytochromes regulate metabolic flux and biomass production by controlling glucose-starch balance and carbon allocation during seedling development.

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

Outcome of radial scar/complex sclerosing lesion associated with epithelial proliferations with atypia diagnosed on breast core biopsy - Results from a multicentric UK based study

The study evaluates the upgrade rate of radial scar/complex sclerosing lesion with atypia to malignancy on surgical excision, finding higher rates with atypical ductal hyperplasia than lobular neoplasia.