Targeted Degradation of METTL3 Against Acute Myeloid Leukemia and Gastric Cancer.
K. Hwang, J. Bae, Y.-L. Jhe, J. Kim, J.-H. Cheong, T. Sim
This study develops KH12, a METTL3 degrader, showing potent anti-leukemia and anti-gastric cancer effects through m6A-dependent and -independent mechanisms.
bioRxiv · Feb 2, 2024Biochemistry