T. Ishida

Under pressure: integrated endothelial cell response to hydrostatic and shear stresses

This study investigates how hydrostatic pressure modulates endothelial cell responses to flow, showing pressure alters shear-induced signaling and transcriptional changes in human and mouse ECs.

ERF and WRKY transcription factors regulate IDA and abscission timing in Arabidopsis.

The paper identifies ERF and WRKY transcription factors that regulate IDA expression and abscission timing in Arabidopsis, with WRKY57 playing a key role in biotic stress responses.

The D-mannose/L-galactose pathway plays a predominant role in ascorbate biosynthesis in the liverwort Marchantia polymorpha but is not regulated by light and oxidative stress

Stress-induced vascular remodeling: novel insight into the role of omega-3 fatty acid metabolite, 4-oxoDHA

This study identifies 4-oxoDHA as a stress-related biomarker linked to vascular inflammation through its regulation of the Nrf2-HO-1 pathway and ICAM-1 expression.

Seed size control via phloem end by callose deposition/degradation of β-1,3-glucanase

The paper identifies a mechanism for seed size regulation through callose deposition/degradation at the phloem end of the ovule, mediated by β-1,3-glucanase genes.

Biosynthesis of gibberellin-related compounds modulates far-red light responses in the liverwort Marchantia polymorpha

This study shows that GA-related compounds in liverworts modulate far-red light responses, revealing evolutionary conservation and functional divergence in GA biosynthesis.

Targeted protein degradation via intramolecular bivalent glues

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

CLE42 Delays Leaf Senescence by Antagonizing Ethylene Pathway in Arabidopsis

This study identifies CLE42 as a negative regulator of leaf senescence in Arabidopsis, showing it delays senescence by suppressing the ethylene pathway.

A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

This study identifies a transcriptional network involving SCL28 and AtSMOS1 that regulates cell size and number in Arabidopsis by controlling G2 phase transitions through CDK inhibitors.

Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types

This paper identifies two amiloride derivatives that inhibit bacterial motility across multiple strains and stator types, including both Na+ and H+ powered motors.

The rapid evolution of flagellar ion-selectivity in experimental populations of E. coli

The paper shows that E. coli can rapidly revert a CRISPR-induced Na+-powered flagellar motor to H+-powered by evolving new mutations, revealing adaptability and modularity of the motor complex.

Reduction of Short-Chain Fatty Acid-Producing Gut Microbiota Leads to Transition from Rapid-Eye-Movement Sleep Behavior Disorder to Parkinson's Disease

The paper analyzes gut microbiota in RBD and PD patients, finding increased Akkermansia and decreased SCFA-producing bacteria in PD, suggesting a link between gut dysbiosis and disease progression.

Divergence and introgression in small apes, the genus Hylobates, revealed by reduced representation sequencing

This study uses reduced representation sequencing to analyze divergence and introgression in Hylobates gibbons, revealing a complex evolutionary history with multiple divergence events and hybridization.

Distinct chemotactic behavior in the original Escherichia coli K-12 depending on forward-and-backward swimming, not on run-tumble movements

This study identifies a novel swimming behavior in E. coli K-12 strain ATCC10798, driven by forward-and-backward motion rather than run-tumble, linked to a mutation in FliC.

Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region.

The paper identifies mutations in the sodium-powered bacterial flagellar motor stator PotB that confer resistance to phenamil, showing that mutations near the peptidoglycan-binding region enable motor function in the presence of the inhibitor.