M. Abe

Sex-dependant differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice.

This study investigates sex-dependent effects of nicotine on discrimination learning and cognitive flexibility in mice, finding differential impacts on visual discrimination and reversal learning tasks.

Bilateral regulation of EGFR activity and local PI dynamics observed with superresolution microscopy

This study uses super-resolution microscopy to show that EGFR and PI(4,5)P2 nanodomains coaggregate before EGF stimulation, and their interaction is regulated by phospholipase Cγ and PI(4,5)P2 levels.

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

This study identifies ULK1 as the kinase responsible for phosphorylating p62, which activates NRF2 in a redox-independent manner through retention of KEAP1 in p62 bodies.

Dimerization processes for light-regulated transcription factor Photozipper visualized by high-speed atomic force microscopy

This study uses HS-AFM to visualize the dimerization process of the photoresponsive TF Photozipper under light and dark conditions, showing how the bZIP domain changes structure during dimerization.

Hypoxic conditions promote Candida glabrata colonization in the intestinal tract and EPA6 plays a significant role in hypoxic adhesion to intestinal cells

This study shows hypoxia enhances Candida glabrata adhesion to intestinal cells, with EPA6 playing a key role in this process.

Genetic and functional odorant receptor variation in the Homo lineage

The paper uses ancient DNA to study olfactory receptor variation in Homo, finding conserved structures in relatives but functional differences in H. sapiens that may expand adaptive capacity.

Membrane cholesterol interferes with tyrosine phosphorylation but facilitates the clustering and signal transduction of EGFR

This study shows that cholesterol affects EGFR mobility, clustering, and signaling by altering membrane subdomain structure and lipid composition.

A novel nuclear speckle factor, USP42, promotes homologous recombination repair by resolving DNA double-strand break induced R-loop

This study identifies USP42 as a nuclear speckle factor that promotes homologous recombination repair by resolving R-loops and facilitating BRCA1 recruitment to DNA double-strand breaks.

Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors

The paper uses single-molecule imaging to assess ligand effects on GPCRs by monitoring diffusion dynamics on the cell surface, showing that diffusion coefficients correlate with receptor activity.