Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance
C. Pauli, M. Kienhoefer, M. Blank, O. Begik, C. Rohde, D. Heid, F. Xu, S. M. N. Zimmermann, K. Weidenauer, S. Delaunay, N. Krall, K. Trunk, D. Zhao, F. Zhou, A. Heit-Mondrzyk, , M. Frye
The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.
bioRxiv · Jul 13, 2024 · PreprintCell Biology