Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages
N. S. De Silva, G. P. F. Nader, F. Nadalin, K. de Azevedo, M. Couty, A. Bhargava, C. Conrad, M. Maurin, C. Fouillade, A. Londono-Vallejo, R. Behrendt, L. Gallwitz, P. Saftig, B. Herrero Fernandez, J. M. Gonzalez-Granado, , N. Manel
This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.
bioRxiv · Feb 17, 2022Immunology