A. Boissonnas

Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development

The paper shows that loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis by increasing liver cholesterol and reducing cholesterol regulation.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

This study characterizes monocyte-to-macrophage differentiation in kidney cancer using scRNA-seq, linking immune phenotypes to T cell function and patient outcomes.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

LOX-1+ immature neutrophils predict severe COVID-19 patients at risk of thrombotic complications

Two new immature and dysfunctional neutrophil cell subsets define a predictive signature of sepsis useable in clinical practice

The paper identifies two new immature and dysfunctional neutrophil subsets that serve as an early blood signature for sepsis, detectable by routine flow cytometry.

Revising CX3CR1 expression on murine classical and non-classical monocytes

The paper revises the classification of murine classical and non-classical monocytes by showing that CX3CR1 expression levels do not strictly correlate with EGFP reporter levels in Cx3cr1+/EGFP mice.