S. Fu

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

This study uses single-cell transcriptomics to analyze GBM tumor microenvironment, identifying immunosuppressive macrophage subtypes and exhausted NK cells, suggesting therapeutic targets.

An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling

This study shows that a CILK1 variant linked to epilepsy impairs primary cilia and Hedgehog signaling by disrupting KATNIP regulation in mouse cells.

High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples

This paper develops a high refractive index imaging buffer to improve 3D SMLM imaging depth in thick samples by reducing RI mismatch and enhancing image quality.

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

This study shows that chemoreceptor clusters and flagellar motors colocalize at the same pole in Pseudomonas aeruginosa, controlled by FlhF, and that CheY overexpression increases c-di-GMP, causing cell aggregation.

Fast and universal single molecule localization using multi-dimensional point spread functions

This paper introduces a GPU-based B-spline PSF modeling method for fast and accurate high-dimensional single molecule analysis.

Optimal Sampling Rate for 3D Single Molecule Localization

This study evaluates how different PSF shapes affect 3D localization accuracy under varying sampling rates and noise conditions, identifying optimal pixel sizes for each PSF.

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

High prevalence of antibiotic resistance in traditionally fermented foods as a critical risk factor for host gut antibiotic resistome

This study finds that consuming traditionally fermented foods increases antibiotic resistance in gut microbiota, posing a public health risk.

A stable reference human transcriptome and proteome as a standard for reproducible omics experiments

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

Field dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging

This paper introduces FD-DeepLoc, a deep learning method for high-throughput 3D super-resolution imaging over a large field of view using a sCMOS camera.

Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

Deformable Mirror based Optimal PSF Engineering for 3D Super-resolution Imaging

This paper develops a framework for generating device-specific optimal PSFs for 3D super-resolution imaging using deformable mirrors, demonstrating superior performance over conventional PSFs.

Drivers of nematode diversity in forest soils across climatic zones

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

Processing Stage Flexibility of the SNARC effect: Task Relevance or Magnitude Relevance?

This study investigates the SNARC effect's processing stage flexibility by comparing magnitude and parity Stroop effects across tasks, finding magnitude-relevant interference information primarily influences the SNARC effect.

Generating Electricity from Water Evaporation Through Microbial Biofilms

This paper demonstrates that engineered microbial biofilms can generate electricity from water evaporation, achieving power densities higher than non-biological materials.

Single-cell transcriptome analysis reveals mesenchymal stem cells in cavernous hemangioma

This study identifies mesenchymal stem cells in cavernous hemangioma using scRNA-seq and proposes their origin from epiblast stem cells, along with new cell types and molecular mechanisms involved in tumor formation and immune responses.

Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

Disordered climate threatens short-distance migrants

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

Metabolic Complementation between Glucose and Amino Acid Drives Hepatic De Novo Lipogenesis and Steatosis

The paper identifies glucose and amino acid contributions to hepatic de novo lipogenesis and steatosis in obesity using metabolic tracing and in vivo studies.

Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy

This paper introduces a label-free imaging cytometry method using deep learning to predict subcellular features from reflectance microscopy, achieving higher accuracy and throughput for single-cell analysis.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

Compartmentalization of enhanced biomolecular interactions for high-throughput drug screening in test tubes

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

Cleavage of a pathogen apoplastic protein by plant subtilases activates immunity

This study shows that cleavage of a pathogen protein by plant proteases activates immunity, while pathogens counteract this with inhibitors.

ER stress drives ER-to-Golgi trafficking of ATF6 by blocking its membrane insertion

The paper challenges the current model of ER stress sensing by showing ATF6 is sorted to the Golgi as a peripheral membrane protein, and translocon inhibition drives its activation.

Bone morphogenetic protein 9 induces osteogenic differentiation of germ cell 1 spermatogonial cells

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

Widespread arginine phosphorylation in human cells - a novel protein PTM revealed by mass spectrometry

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

This study uses vnOCT to detect early retinal changes in a dexamethasone-induced ocular hypertension mouse model, finding that VN ratio and A-V sO2 correlate with RGC loss independent of IOP.

Evolutionary branching of host resistance induced by density-dependent mortality

This study investigates how density-dependent mortality influences the evolutionary dynamics of host resistance, finding that trade-off curves determine whether resistance evolves continuously or through branching.

Faster carbon accumulation in global forest soils

The paper introduces a new method to estimate soil organic carbon stocks by accounting for soil volume changes, revealing an additional carbon sink in global forests.