Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics
H. B. Kolla, A. Kumar, R. H. Nanjunadappa, B. Hilyard, M. Dutt, D. Chauhan, J. Marshall, D. Kelvin, C. S. Umeshappa
This paper designs a multi-epitope tolerogenic vaccine targeting CYP2D6 for autoimmune hepatitis using immuno-informatics, showing it induces IL-10 and programs dendritic cells toward a tolerogenic state.
bioRxiv · Apr 17, 2024 · PreprintImmunology