Responding kinetic of B-cell receptor repertoire to the Toll-like receptor 7/8 stimulation in non-human primates
S. Wang, J. Mandl, M. Feinberg, M. Citron, N. K. Saksena, L. Luo, Z. Li, Y. Zhu, T. Li, C. Nie, X. Zhang, Y. Liu, X. Liu, I.-M. Wang, W. Zhang
This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.
bioRxiv · Mar 15, 2021 · PreprintImmunology