Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome
D. Hornburg, S. Ferdosi, M. Hasan, B. Tangeysh, T. R. Brown, T. Wang, E. M. Elgierari, X. Zhao, A. Alavi, J. Chu, M. Figa, W. Tao, J. Wang, M. Goldberg, H. Xia, , O. C. Farokhzad
The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.
bioRxiv · Jan 8, 2022 · PreprintBiophysics